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8 months placebo-controlled mortality morbidity study of norvasc 5 10 mg in 1153 patients with nyha classes iii n 931 or iv n 222 heart failure on stable doses of diuretics, digoxin, and ace inhibitors, norvasc had no effect on the primary endpoint of the study which was the combined endpoint of all-cause mortality and cardiac morbidity as defined by life-threatening arrhythmia, acute myocardial infarction, or hospitalization for worsened heart failure , or on nyha classification, or symptoms of heart failure.
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no increase in mortality was observed in patients taking digoxin as concomitant medication.
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– spironolactone inhibits the excretion of digoxin by the kidneys, and probably reduce its volume of distribution.
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this medicine may interact with the following medications -certain medicines for blood pressure, heart disease, irregular heart beat -clonidine -digoxin -diuretics -dobutamine -epinephrine -isoproterenol -nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -reserpine.
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