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Drugs including januvia belong to a new class of type 2 diabetes drugs known as incretin mimetics, which work to lower blood sugar levels by controlling the gastrointestinal hormone responsible for releasing insulin glucagon-like peptide-1 glp-1 .

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figure 2 mean change from baseline for a1c over 52 weeks in a study comparing januvia to glipizide as add-on therapy in patients inadequately controlled on metformin per protocol population .

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therefore, januvia is not an inhibitor of cyp3a4-mediated metabolism.

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have been taking januvia 100mg with glyburide and glucaphage for 3 months my a1c went from 8.

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