6 1 combinations of olmesartan medoxomil and hydrochlorothiazide were administered to pregnant mice at oral doses up to 1625 mg kg day 122 times the maximum recommended human dose mrhd on a mg m basis or pregnant rats at oral doses up to 1625 mg kg day 280 times the mrhd on a mg m basis .
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studies in which hydrochlorothiazide was orally administered to pregnant mice and rats at doses of up to 3000 and 1000 mg kg day, respectively, provided no evidence of harm to the fetus.
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